Flight José Marti International Airport departs from Havana José Marti International Airport at 07:22 and arrives at Panama City Tocumen International Airport at 10:06.
The flighttime is about 3h 44m. The distance travelled ("as the bird flies"): 414 Km. So the average speed is roughly 111 Km.
There is an 1 hour time difference between Havana and Panama City