Please be aware that Rome has multiple airports and that these results are for all airports serving the city.
The best month to fly between Rome and Amsterdam is July and the most expensive month to fly is September. (Average prices, based on 970 datapoints.)
The best day to arrive at Rome is Monday and it would be best to avoid Thursday, as prices are on average 45.18% higher than on Monday. (Average prices, based on 970 datapoints.)
The best time to fly is at around 8. (Average prices, based on 1482 datapoints.)