Flight Tocumen International Airport departs from Panama City Tocumen International Airport at 21:49 and arrives at Havana José Marti International Airport at 01:29.
The flighttime is about 2h 40m. The distance travelled ("as the bird flies"): 414 Km. So the average speed is roughly 155 Km.
There is an 1 hour time difference between Panama City and Havana