Flight Istanbul Atatürk Airport departs from Istanbul Istanbul Atatürk Airport at 17:10 and arrives at Rome Leonardo da Vinci–Fiumicino Airport at 18:40.
The flighttime is about 2h 30m. The distance travelled ("as the bird flies"): 1844 Km. So the average speed is roughly 738 Km.
There is an 1 hour time difference between Istanbul and Rome