Flight La Guardia Airport departs from New York La Guardia Airport at 07:55 and arrives at San Francisco International Airport at 17:41.The flight has a short stop at Denver. The flighttime is about 12h 46m. The distance travelled ("as the bird flies"): 5391 Km. So the average speed is roughly 422 Km. There is an 3 hour time difference between New York and San Francisco